Sara Blumer-Schuette

Sara Blumer-Schuette
Associate Professor, Ph.D.
331 MSC
248-370-3168
Lab location: 330 MSC
Lab phone: (248) 370-4903
blumerschuette@www.zhongqiwg.com

Blumer-Schuette Lab Website

Courses:

BIO 1200 Biology I
BIO 3500 General Microbiology
BIO 4511 Microbial Biotechnology

Microbial Physiology and Genomics

Non-model environmental microorganisms are promising reservoirs of unique metabolic pathways that can be harnessed to replace traditional synthetic chemistry. Professor Blumer-Schuette’s research interests include microbial physiology and genomics of non-model microorganisms living at the extremes of life. Current projects include unraveling mechanisms used by extremophilic microbes to interact with substrates that they require as an energy source. Given the intense competition in microbial biospheres, the ability to efficiently harness energy sources, be they organic or inorganic, is crucial for microbes. Implications for understanding these mechanisms range from outlining how microbial attachment mechanisms have functionally evolved, to the environmental implications of these mechanisms and identifying targets for rational design of commercially relevant microbes. Other research interests include characterizing transport systems used to secrete large (some over 200 kDa) enzymes by monoderm bacteria, and how to optimize secretion efficiency of these systems. In the Blumer-Schuette lab, students can expect to use a combination of anaerobic and aerobic microbiology, functional genomics, microbial genetics and biochemistry in their research projects.

选择出版物:

Sara Blumer-Schuette NCBI publication list

Khan*, A.M. Khan, V.J. Hauk*, M. Ibrahim*, T.R. Raffel and S.E Blumer-Schuette. (2020).Caldicellulosiruptor besciiadheres to polysaccharides using a type IV pilin-dependent mechanism.Applied and Environmental MicrobiologyPosted online February 21, 2020 DOI:10.1128/AEM.00200-20.

Khan*, A., C. Mendoza, V. Hauk* and S. Blumer-Schuette. (2019).Genomic and physiological analyses reveal that extremely thermophilicCaldicellulosiruptor changbaiensisdeploys uncommon cellulose attachment mechanisms.Journal of Industrial Microbiology & Biotechnology46: 1251-1263.DOI:10.1007/s10295-019-02222-1.

Mendoza, C. and S.E. Blumer-Schuette. (2019). Complete genome sequence ofCaldicellulosiruptor changbaiensisCBS-Z, an extremely thermophilic, cellulolytic bacterium isolated from a hot spring in China.Microbiology Resource Announcements8: e00021-19. DOI:10.1128/MRA.00021-19.

Mitchell*, J, S.J. Kim, G. Koukos, A. Seelmann*, B. Veit*, B. Shepard*, S. Blumer-Schuette, H.S. Winter, D. Iliopoulos, C. Pothoulakis, E. Im, and S.H. Rhee. (2018).Colonic inhibition of phosphatase and tensin homolog increases colitogenic bacteria, causing development of colitis in Il10-/- Mice.Inflammatory Bowel Disease24(8):1718-1732.DOI:10.1093/ibd/izy124.

Lee, L.L., S.E. Blumer-Schuette, J.A. Izquierdo, J.V. Zurawski, A.J. Loder, J.M. Conway, J.G. Elkins, M. Podar, A. Clum, P.C. Jones, M.J. Piatek, D.A. Weighill, D.A. Jacobson, M.W.W. Adams and R.M Kelly. (2018). Genus-wide assessment of lignocellulose utilization in the extremely thermophilic genusCaldicellulosiruptorby genomic, pangenomic, and metagenomic analyses.Applied Environmental Microbiology84: e02694-17. DOI:10.1128/AEM.02694-17.

Blumer‐Schuette, S.E., J.V. Zurawski, J.M. Conway, P. Khatibi, D.L. Lewis, Q. Li, V.L. Chiang and R.M. Kelly. (2017).Caldicellulosiruptor saccharolyticustranscriptomes reveal consequences of chemical pretreatment and genetic modification of lignocellulose.Microbial Biotechnology10: 1546-1557. DOI:10.1111/1751-7915.12494.

Blumer-Schuette, S.E., M. Alahuhta, J.M. Conway, L.L. Lee, J.V. Zurawski, R.J. Giannone, R.L. Hettich, V.V. Lunin, M.E. Himmel and R.M. Kelly. (2015). Discrete and structurally unique proteins (tāpirins) mediate attachment of extremely thermophilicCaldicellulosiruptorspecies to cellulose.Journal of Biological Chemistry. DOI:10.1074/jbc.M115.641480.

Blumer‐Schuette, S.E., S.D. Brown, K.B. Sander, E.A. Bayer, I. Kataeva, J.V. Zurawski, J.M. Conway, M.W.W Adams andR.M. Kelly.(2014). Thermophilic lignocellulose deconstruction.FEMS Microbiology Reviews38: 393-448. DOI:10.1111/1574-6976

Frock, A.D., C.I. Montero, S.E. Blumer-Schuette andR.M. Kelly.(2013). Stationary phase and nutrient levels trigger transcription of a genomic locus containing a novel peptide (TM1316) in the hyperthermophilic bacteriumThermotoga maritima.Applied and Environmental Microbiology79: 6637-6646. DOI:10.1128/AEM.01627-13

Blumer-Schuette, S.E., R.J. Giannone, J.V. Zurawski, I. Ozdemir, Q. Ma, Y. Yin, Y. Xu, I. Kataeva, F.L. Poole II, M.W.W. Adams, S.D. Hamilton-Brehm, J.E. Elkins, F.W. Larimer, M.L. Land, L.J. Hauser, R.W. Cottingham, R.L. Hettich andR.M. Kelly.(2012).Caldicellulosiruptorcore and pangenomes reveal determinants for noncellulosomal thermophilic deconstruction of plant biomass.Journal of Bacteriology194: 4015-4028. DOI:10.1128/JB.00266-12

Blumer-Schuette, S.E., D.L. Lewis andR.M. Kelly.(2010). Phylogenetic, microbiological, and glycoside hydrolase diversities within the extremely thermophilic, plant biomass-degrading genus Caldicellulosiruptor.Applied and Environmental Microbiology, 76: 8084-8092. DOI:10.1128/AEM.01400-10.

*OU student